The Indomitable Lions last faced the five-time World Champions at the 2014 Fifa World Cup in Brazil.
The Brazilian Football confederation has confirmed the November 20 match, which will come four days after Cameroon face Morocco in a 2019 Africa Cup of Nations preparation game.
With Cameroon set to host next year’s Afcon finals, they are participating in the qualifiers to earn game time and the Brazil friendly provides them with the highest standard of preparation for the tournament.
In the last meeting between the two sides Brazil won 4-1 with Neymar grabbing a double.
While it is a friendly match, the game would be a stern test for Cameroon coach Clarence Seedorf, who is yet to impress since taking over as Cameroon coach in August.
Seedorf has led African reigning champions Cameroon to uninspiring draws against Comoros and Malawi as well as an unimpressive 1-0 win over Malawi.
For Brazil coach Tite, it would be his first ever match against African opposition as manager.