India could soon have its second domestically developed coronavirus vaccine even as a deadly second wave shows no signs of slowing down anytime soon.
Drugmaker Cadila Healthcare, also known as Zydus Cadila, is conducting phase three clinical trials on 28,000 people, including those above 75 and children between ages 12 and 18, for its DNA-based vaccine candidate.
“We have completed the major recruitment for our phase three (trial),” managing director Sharvil Patel told CNBC’s “Street Signs Asia” on Thursday.
He said the company expects efficacy data from the phase three trial to come out next month after which, it would seek emergency use authorization from the Indian drug regulator in mid-May.
“On the safety and efficacy in our phase two (trials) as well as ongoing phase three, we’ve seen very good data on safety and strong data on immunogenicity, comparable to most of the other vaccines that are there,” Patel said.
Vaccination campaign
India began its vaccination campaign in January and as of Thursday, government data showed more than 150 million doses have been administered. But only about 25.8 million second doses have been administered.
Currently, India is using the AstraZeneca vaccine, locally known as Covishield and produced by the Serum Institute of India, and Bharat Biotech’s Covaxin.
New Delhi has also recently approved the Russia-developed Sputnik V and authorized foreign-made vaccines that have been granted emergency approval by the U.S., U.K., European Union, Japan, and World- Health Organization-listed agencies.
Patel told CNBC that Zydus’ candidate uses a technology that allows it to quickly modify the vaccine for mutated variants of the virus. The drugmaker has a new facility that it plans to use to ramp up production once it receives regulatory approval.
“Initially, we will start off with producing 10 million doses a month and as soon as in the next four to five months we are looking (at) how do we double the capacity to 20 million doses per month,” Patel said.
1 in 3 new cases from India
So far in April alone, India has reported more than 6.2 million cases and over 42,000 officially counted deaths — reports suggest the death toll may be undercounted.
The World Health Organization in its weekly epidemiological update on the pandemic said that last week, India accounted for 1 in 3 cases reported globally. In its analysis, the WHO said India had 157.4 new cases and 1.1 new deaths per 100,000 people.
On Thursday, India’s health ministry data showed there were 379,257 new cases. The death toll has jumped this month and the latest official figure said at least another 3,645 people have died over a 24-hour period.
Experts fear that a mutated variant of the coronavirus is responsible for the dramatic surge in cases. The WHO said in its weekly update that reports suggest there are multiple variants of the virus circulating in India.
