DeSean Jackson went OFF on Danny Green during L.A.’s stunning loss to Portland on Tuesday … with the NFL star calling the Lakers wing “weak,” a “bum” and straight-up “trash.”

“I don’t care what anybody say,” said the Philadelphia Eagles receiver, who grew up in L.A. “Danny Green, you weak as f*ck. You out there playing like a bum.”

“Get him off the team, man. Trash.”

Of course, Green didn’t play his best in the Lakers’ 100-93 playoff loss to the Trailblazers … scoring just 10 points on 4-of-12 shooting.

In fact, Green, Kentavious Caldwell-Pope and Alex Caruso were all heavily criticized by NBA pundits for not giving LeBron James enough support in the game.

Seems DeSean couldn’t agree more … because he said he now believes the Lake Show is in big trouble in the rest of the series.

“I told ya’ll Lakers, ya’ll in trouble,” DeSean said. “I’m a die-hard Laker fan, but I don’t know. This ain’t looking like us.”

Jackson went on to praise the hell out of Damian Lillard for his 34-point night … adding, “That boy Dame Lillard cold. Salute, Dame.”

Game 2 in the series is set to tip-off Thursday … and there’s already been talks J.R. Smith and/or Dion Waiters should begin eating into Green’s minutes.

Something tells us Jackson’s okay with that idea …