Tom Brady and a craps table in Florida apparently have something in common … neither stands a chance against Eli Manning!!!

360aproko Sports has learned … the New York Giants legend rolled dice at the Seminole Hard Rock Hotel & Casino in Hollywood, FL for hours on Thursday night — and he appeared to win BIG.

One witness tells us … Manning showed up before 9:30 PM and stayed past 2:30 AM — albeit with a short break for food at some point — seemingly raking in cash throughout the evening.

In fact, in video we obtained, you can see that after one run in particular … he celebrated like a madman, high-fiving his tablemates before sharing a huge embrace with one of his pals.

We’re told Eli seemed to have around $40,000 in chips in front of him … while some of the guys he was playing with had over $100K.

Of course, it ain’t like Eli exactly needs the dough … after all, the former signal-caller made over $250 MILLION in his NFL career alone.

But, hey, the guy beat Brady twice in Super Bowls — he clearly can’t help but win when he gets the chance!