President Donald Trump’s executive order making it easier to fire federal employees is meeting fierce resistance within the Food and Drug Administration, amid fears the White House is planning a purge of senior health officials it views as disloyal.

The order — which Trump issued on Oct. 21 — would strip certain civil service and due process protections from career federal employees who make policy.

FDA officials see it as laying the groundwork for an across-the-board effort to replace longtime career scientists with political allies in a second Trump term. Tensions between the agency and Trump’s inner circle have grown over the past couple of months, as White House aides have sparred with the FDA over efforts to fulfill the president’s vow of a coronavirus vaccine before Election Day.

Multiple top FDA officials have raised concerns about the executive order directly to Commissioner Stephen Hahn in recent weeks, voicing sharp opposition to the prospect of determining which employees would be eligible, said two health officials with knowledge of the matter.

That group includes Patrizia Cavazzoni, the acting head of the FDA’s drug center, who has suggested that she might submit a blank document if required to draw up a list of eligible workers, according to an FDA official familiar with the discussion.

Hahn, meanwhile, has told officials that if the agency is forced to comply with the order, he’ll rely solely on his six center directors to determine which career civil servants are covered by it — a move seen within the FDA as a tacit endorsement of keeping the agency’s list as short as possible.

“There’s a legitimately palpable fear this could be wielded as a weapon to nix everyone,” the FDA official said of the executive order. “They see this as an opportunity to round up all the scientists who have been perceived to have been causing an obstruction.”

In response to a series of questions, an FDA spokesperson said the agency continues to “evaluate the executive order to determine appropriate next steps.” But after publication of this story, the spokesperson called the characterization of the FDA’s internal discussions around the order “patently false.”

An HHS spokesperson said the department is still evaluating its implementation of the order.

The guidance issued by the White House so far has been vague. A late October memo from the Office of Personnel Management gave agencies 90 days — or roughly until Inauguration Day — to draw up and submit initial lists of positions eligible for reclassification under the order.

The sweeping mandate, which came with no advance warning, prompted immediate pushback both inside and outside the administration.

The National Treasury Employees Union, which represents career officials across several agencies, is already suing to strike down the order. And Ronald Sanders, the Trump administration-appointed head of an advisory council on civil service, resigned in protest of the policy.

“It was accountability more to political loyalty than it was high performance,” Sanders said of his interpretation of the order’s goal. “So that was my red line.”

Health agencies are especially worried about the fallout from the president’s order, according to a half-dozen officials across the Department of Health and Human Services. Its work to combat the pandemic has conflicted with Trump’s efforts to downplay the threat and swiftly reopen the economy, leading to a series of high-profile clashes over public health guidance, key economic decisions and even the true severity of the crisis.

The FDA is viewed as particularly vulnerable, given its heavy reliance on career scientists across a range of regulatory areas and its recent battles with top Trump aides over standards for coronavirus vaccines.

White House officials have also previously discussed trying to stock agencies like the Centers for Disease Control and Prevention with more political appointees in an effort to exert greater control over its decision-making.

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And on Sunday, Trump suggested he would fire Anthony Fauci, the director of National Institute of Allergy and Infectious Diseases, soon after Election Day, in what some officials saw as a foreshadowing of a widespread overhaul to come if the president wins reelection.

National institutes of Health staff “absolutely think it’s aimed at Fauci,” one senior NIH official said of the order.

Fauci declined to comment. And even under the executive order, it’s unlikely that Trump could directly remove him without the support of National Institutes of Health Director Francis Collins or HHS Secretary Alex Azar, due to a carve-out that excludes officials in the government’s Senior Executive Service from being reclassified.

Collins has ardently backed Fauci in recent weeks, even as Trump and his allies amped up their complaints, saying Oct. 23 that the agency needs “more Tony Faucis — we don’t have enough of them.”

Yet beyond Fauci, the order would still cover thousands of civil servants across the federal government’s health agencies, allowing Trump to effectively remake the federal bureaucracy over the next four years.

“The targeted population isn’t the Dr. Faucis of the world, it’s the people who provide him with information, who write the reports, who analyze the studies and conduct the studies and who keep people like him informed and political appointees informed,” said Jacqueline Simon, policy director for the American Federation of Government Employees.

The FDA is particularly at risk, due largely to a quirk in its hiring practices. The agency over the last few years has reclassified dozens of career scientists under a special authority created by Congress that allows it to pay them higher salaries in an effort to retain top talent.