The Premier League is finally back after 100 days off due to COVID-19 … and the players made a profound statement at kick-off by taking a knee to honor George Floyd.

All players for Aston Villa and Sheffield United — as well as the referees — participated in the demonstration on Wednesday … showing solidarity with the fight against police brutality and social injustice.

Along with taking a knee, all players are wearing “Black Lives Matter” on the back of their jerseys.

The EPL acknowledged the gesture on Twitter … saying, “There is #NoRoomForRacism, anywhere.”

The players made their intentions clear in a joint statement last week … saying, “We, the Players, stand together with the singular objective of eradicating racial prejudice wherever it exists, to bring about a global society of inclusion, respect, and equal opportunities for All, regardless of their colour or creed.”

“This symbol is a sign of unity from all Players, all Staff, all Clubs, all Match Officials and the Premier League #blacklivesmatter #playerstogether.”